Phenburterol is marketed as a “maximum strength fat burning catalyst” and is a dietary supplement developed by MuscleMeds Performance Technologies. The manufacturer claims that this product introduces a new development in advanced fat burning technology by activating Uncoupling Protein 1 (UCP-1)

UCP-1 Fat Burning Technology

Phenbuterol claims to provide enhanced fat burning technology, which is made possible though the activation of UCP-1 (Uncoupling Protein 1). UCP-1 is said to increase fat burning in brown adipose tissues. Essentially, it supposedly stimulates a process in the body known as thermogenesis, which burns fat and calories as fuel to heat the body.

It is interesting to note that when this Phenbuterol review was created, the official product webpage states that “Phenbuterol is a trade name and is not intended to depict any comparison to any pharmaceutical or other product of any particular benefit thereof.” This is difficult to believe, because if the manufacturer was not intending to depict any comparison, it would have avoided using “Phen” within the product name, which automatically calls to mind the prescription diet pill Phentermine. 

Phenbuterol Ingredients

The Phenbuterol formula contains the following ingredients:

  • Caffeine Anhydrous,
  • Ilex Paraguariensis Leaf Extract,
  • Grains of Paradise Seed Extract,
  • Rauwolfia Serpentia Extract,
  • Advantra Z (Citrus Aurantium Extract, N-methyltyramine, Octopamine, Hordenine, and Tyramine)

The official webpage for Phenbuterol does provide some information with regards to research that has been conducted on the ingredients that make up this fat burning product. The site also offers some basic information detailing how these various substances are meant to provide the promised benefits. However, when the links to the cited studies are followed, it rapidly becomes clear that there is very slim evidence supporting the claims that the manufacturer has made about the effectiveness of the formula.

More to the point, there is no clinical proof that the Phenbuterol formula will cause fat burning to any degree that will lead to measurable fat loss. 

This Diet Pill May Be Unsafe

Another aspect that is concerning about this supposed fat burner is that the manufacturer doe not list any potential side effects of the formula, nor does it warn that side effects are possible. This is surprising to say the least, especially considering the number of stimulants in this product.

This does not speak to the willingness of that company to provide potential users with important information, as there are a number of ingredients within this formula that can lead to unwanted symptoms. To begin with, this product includes caffeine. This stimulant, which can be helpful in fat burning and energy boosting, is also associated with side effects such as sleep struggles, anxiety, restlessness, and jitters. Moreover, that substance can also increase blood pressure and heart rate.

This product also contains citrus aurantium, also known as bitter orange. That ingredient contains the stimulants synephrine and octopamine. Synephrine affects the nervous system, squeezing blood vessels, increasing blood pressure, and causing the heart to beat faster. Additionally, the combinations of synephrine and caffeine can increase blood pressure and heart rate, even in healthy adults.

As for Octopamine, it is a stimulant compound that is thought to have minor fat burning effects, although these effects have not been seen in humans. More importantly, octopamine was banned by the WADA (World Anti-Doping Agency) for its stimulatory properties.

Due to the number of stimulants in this product, it is highly recommended that you speak with a doctor before considering the use of this weight loss pill. This is especially important if you have a known medical condition, are taking medications or other supplements, or are pregnant or nursing.

At the time that this review was created, a single box of Phenbuterol containing 30 capsules could be purchased for $29.99. 

September 2019 Update: Phenbuterol can still be found for purchase online on various sites, including Walmart’s online store, although there it is currently listed as “out of stock.”  That being said, it appears as though this product has been either permanently discontinued by the manufacturer or it has been released under a new name as it is no longer listed on the official MuscleMeds site.


Nuphedrine is an over-the-counter (OTC) diet pill with “clinically proven weight loss technology”. According to the official website for this product at the time that this review was written, it is the “only pill to bring you both: real certified South African Hoodia & Patented Advantra-Z”. It was designed to help you burn more calories every day, enhance the ratio of lean muscle, reduce weight, stimulate thermogenesis, suppress your appetite, and boost athletic performance when used in conjunction with diet and exercise.

When this review was written, Nuphedrine contained the following ingredients within its proprietary formula: Advantra-Z (citrus aurantium), Hoodia Gordonii, and Slimaluma (caralluma fimbriata). 3 capsules make up one serving and each serving contains 1500mg of the proprietary blend.

Users are instructed to either follow the directions on the bottle or the directions of their healthcare provider when taking Nuphedrine. The product’s directions are to take 3 capsules daily with plenty of water: 2 capsules should be taken in the morning on an empty stomach and 1 capsule should be taken in the afternoon. In addition, keep in mind that for optimal results, this diet pill should be used alongside conventional weight loss methods, including a calorie-conscious diet and regular exercise.

While Nuphedrine does contain ingredients that have been clinically researched by scientists to determine their effects and how they work in the body, these ingredients have never been clinically proven to cause weight loss.

What is known about Advantra-Z, which is a patented version of the herb citrus aurantium (bitter orange) is that it works on the central nervous system and increases heart rate, which can help to boost metabolism. This may lead to more fat burning, particularly when combined with physical exercise. It’s effects are due to synephrine, a natural occurring stimulant found in citrus aurantium. That said, some research has found that because of synephrine’s ability to increase heart rate and raise blood pressure, it may not be safe to use as a dietary supplement as it could have harmful effects in some people, including serious cardiovascular effects (heart attack, stroke, etc.), particularly when combined with other stimulants such as caffeine.

Simaluma is believed to help suppress appetite. Some research has found that caralluma fimbriata – a cactus plant – may help to assist in the reduction of hunger, which can lead to a reduced calorie intake. However, no research has found this herb to have any measureable effect on weight loss.

Hoodia has long been touted as an appetite suppressant used for centuries by South African bushmen, but not clinical study has ever proven that the herb – regardless of its level of purity – suppresses hunger.

Due to this product containing citrus aurantium, prior to taking Nuphedrine, it is recommended that you consult with your healthcare provider to make sure that this is a safe product for you. This is especially important if you are currently taking medications or other supplements or if you have a medical condition or are pregnant, nursing or planning to become pregnant.