Adiphene

The name of this RDK Global Pharmaceutical product sounds like a fusion of the names of the two prescription diet pills “Adipex” and “Phentermine”. Adiphene has primarily been designed to reduce fat, which the manufacturer claims is made possible through its 12 different ingredients that “help you tackle fat in five different ways.”

The Adiphene Formula

According to the official product page, at the time this review was written, the Adiphene formula consists of:

  • Vitamin B6
  • L-Carnitine HCL
  • Ginger Root
  • Chitosan
  • Glucomannan
  • Cinnamon Extract
  • Cayenne Capsicum
  • Bitter Orange
  • Chromium Picolinate
  • Guarana Extract
  • Ginseng Panax Root Extract
  • Cacao Extract

More specifically, the benefits that these ingredients provide include:

  • Fat burning – Vitamin B6, L-carnitine HCL, and ginger root extract may help to boost your metabolism and quickly burn off excess fat.
  • Fat binding – Chitosan may bind to fat in the stomach, stopping your body from absorbing this fat during digestion. Instead, fat is expelled from the body as waste.
  • Appetite suppression – Glucomannan may reduce the feelings of hunger, which can help a person eat less, which means that they ingest fewer calories.
  • Thermogenic boosting – Cinnamon extract and cayenne capsicum supposedly help to burn off even more calories by using fat as energy to heat up the body.
  • Energy boosting – Bitter orange, chromium picolinate, guarana extract, ginseng panax root extract, and cacao extract are all natural stimulants that can help to increase energy, assisting in the support of maximum fat burning.

Unlike many other product pages for diet pills, Adiphene’s official site contains details about the ingredients within its formula, providing more than a basic ingredients list. Unfortunately, on the other hand, it does not provide any studies to support its claims.

Risk of Potential Side Effects

Additionally, there are a few concerns about this product. The primary one is the risk of potential side effects due to the number of stimulants in the Adiphene formula. Not only does more than one stimulant increase the risk of unpleasant side effects like sleeplessness, heart palpitations, jitters, mood fluctuations, digestive upset, headache, anxiety, etc. but the combination of bitter orange and ingredients that contain caffeine, like guarana extract, can be dangerous.

Bitter orange contains the stimulant synephrine, and the FDA has warned that when it is combined with caffeine it can increase the risk of severe cardiovascular effects, such as heart attack and stroke. Therefore, it is very important for anyone interested in taking this weight loss supplement to first consult with their medical practitioner.

When this review was written, a 30-day supply of Adiphene cost $69.95.

September 2020 Update

Adiphene, like so many other bogus nonprescription Adipex and phentermine alternatives, has been discontinued. Although it is not known why this product failed to be restocked on the virtual shelves of online retailers like Amazon, or why the manufacturer decided to call it quits, there are a few reasons as to why this product may have been discontinued.

For instance, contributing factors may have been:

  • Lack of efficacy evidence – In the above Adiphene review it was noted that while the manufacturer went that extra mile to talk about the ingredients within the formula, at the same time there were no studies or clinical research provided to backup the claims it made about these ingredients. Times change, laws change and the language that is considered acceptable to describe a product can make or break its success. Today’s consumers are not keen on being misled.
  • Side effects – There were many stimulants in the Adiphene formula. As such, the likelihood of users experiencing adverse effects (e.g. sleeplessness, jitters, etc.), even when taken as recommended on the product label, were likely, even for those who weren’t naturally sensitive to stimulants.
  • Cost – A one month supply cost almost $70! Using this diet pill alongside a weight management strategy could become quite costly for the average user. Not to mention, there has always been plenty of competition in the market and plenty of cheaper options.

About the Caffeine and Synephrine Combo

Regardless of the reasons why Adiphene may have been discontinued, it is important to note that it likely wasn’t because it contained both caffeine and synephrine. When the initial review for this product was written, at the time, the FDA did warn that these two stimulants could be a dangerous combination.

However, since then, more research has been conducted on combined caffeine and synephrine consumption in humans, and while longer term studies are needed to assess both the tolerability and efficacy of these two substances used in combination, overall, when used together, they do not appear to result in any more notable adverse or dangerous effects beyond what a person would experience through the consumption of caffeine alone.

That being said, keep in mind that the greater the amount of these substances used within a formula, the higher the potential risk of negative reactions. At the end of the day, it is often best to simply avoid taking diet pills like Adiphene, that contain multiple stimulant ingredients.