Adiphene

The name of this RDK Global Pharmaceutical product sounds like a fusion of the names of the two prescription diet pills “Adipex” and “Phentermine”. Adiphene has primarily been designed to reduce fat, which the manufacturer claims is made possible through its 12 different ingredients that “help you tackle fat in five different ways.”

The Adiphene Formula

According to the official product page, at the time this review was written, the Adiphene formula consists of:

  • Vitamin B6
  • L-Carnitine HCL
  • Ginger Root
  • Chitosan
  • Glucomannan
  • Cinnamon Extract
  • Cayenne Capsicum
  • Bitter Orange
  • Chromium Picolinate
  • Guarana Extract
  • Ginseng Panax Root Extract
  • Cacao Extract

More specifically, the benefits that these ingredients provide include:

  • Fat burning – Vitamin B6, L-carnitine HCL, and ginger root extract may help to boost your metabolism and quickly burn off excess fat.
  • Fat binding – Chitosan may bind to fat in the stomach, stopping your body from absorbing this fat during digestion. Instead, fat is expelled from the body as waste.
  • Appetite suppression – Glucomannan may reduce the feelings of hunger, which can help a person eat less, which means that they ingest fewer calories.
  • Thermogenic boosting – Cinnamon extract and cayenne capsicum supposedly help to burn off even more calories by using fat as energy to heat up the body.
  • Energy boosting – Bitter orange, chromium picolinate, guarana extract, ginseng panax root extract, and cacao extract are all natural stimulants that can help to increase energy, assisting in the support of maximum fat burning.

Unlike many other product pages for diet pills, Adiphene’s official site contains details about the ingredients within its formula, providing more than a basic ingredients list. Unfortunately, on the other hand, it does not provide any studies to support its claims.

Risk of Potential Side Effects

Additionally, there are a few concerns about this product. The primary one is the risk of potential side effects due to the number of stimulants in the Adiphene formula. Not only does more than one stimulant increase the risk of unpleasant side effects like sleeplessness, heart palpitations, jitters, mood fluctuations, digestive upset, headache, anxiety, etc. but the combination of bitter orange and ingredients that contain caffeine, like guarana extract, can be dangerous.

Bitter orange contains the stimulant synephrine, and the FDA has warned that when it is combined with caffeine it can increase the risk of severe cardiovascular effects, such as heart attack and stroke. Therefore, it is very important for anyone interested in taking this weight loss supplement to first consult with their medical practitioner.

When this review was written, a 30-day supply of Adiphene cost $69.95.

September 2020 Update

Adiphene, like so many other bogus nonprescription Adipex and phentermine alternatives, has been discontinued. Although it is not known why this product failed to be restocked on the virtual shelves of online retailers like Amazon, or why the manufacturer decided to call it quits, there are a few reasons as to why this product may have been discontinued.

For instance, contributing factors may have been:

  • Lack of efficacy evidence – In the above Adiphene review it was noted that while the manufacturer went that extra mile to talk about the ingredients within the formula, at the same time there were no studies or clinical research provided to backup the claims it made about these ingredients. Times change, laws change and the language that is considered acceptable to describe a product can make or break its success. Today’s consumers are not keen on being misled.
  • Side effects – There were many stimulants in the Adiphene formula. As such, the likelihood of users experiencing adverse effects (e.g. sleeplessness, jitters, etc.), even when taken as recommended on the product label, were likely, even for those who weren’t naturally sensitive to stimulants.
  • Cost – A one month supply cost almost $70! Using this diet pill alongside a weight management strategy could become quite costly for the average user. Not to mention, there has always been plenty of competition in the market and plenty of cheaper options.

About the Caffeine and Synephrine Combo

Regardless of the reasons why Adiphene may have been discontinued, it is important to note that it likely wasn’t because it contained both caffeine and synephrine. When the initial review for this product was written, at the time, the FDA did warn that these two stimulants could be a dangerous combination.

However, since then, more research has been conducted on combined caffeine and synephrine consumption in humans, and while longer term studies are needed to assess both the tolerability and efficacy of these two substances used in combination, overall, when used together, they do not appear to result in any more notable adverse or dangerous effects beyond what a person would experience through the consumption of caffeine alone.

That being said, keep in mind that the greater the amount of these substances used within a formula, the higher the potential risk of negative reactions. At the end of the day, it is often best to simply avoid taking diet pills like Adiphene, that contain multiple stimulant ingredients.

PhenBurn 750

PhenBurn 750 is the “high strength version of PhenBurn 375” according to eBody, the manufacturer behind the product. It contains the same ingredients as the other weight loss formula but a double dosage of the PhenBurn proprietary blend.

This OTC weight loss alternative product to prescription Phentermine is said to contain a blend of high quality ingredients to help a person manage weight. It can also apparently help bolster energy to give you greater focus for your workouts as well as can reduce appetite, providing a sense of fullness.

PhenBurn 750 Formula

The PhenBurn 750 formula contains all the same ingredients found in PhenBurn 375, but with double the amount of each. These ingredients include:

  • Caffeine
  • Green Coffee Extract
  • L-Carnitine
  • L-Tartrate
  • Guarana Extract
  • Green Tea Extract
  • Kola Nut Extract

It also includes a Phenburn Proprietary Blend (DL Phenylalanine, Naringin): Conjugated Linoleic Acid, Pyridoxine Hydrochloride, Cyanocobalamin Prep, Chromium Picolinate.

What Studies Have Found

Many of the ingredients used within this formula can be found in several other weight loss products on the market. Furthermore, the majority of them have been clinically tested at one point or another to determine their effectiveness for health and weight loss.

For instance, some research involving caffeine have found it to be an energy booster that can encourage alertness. Some even believe that in certain people, caffeine may help to suppress appetite. On the other hand, L-carnitine is thought to help with fatty acid metabolism, green tea is believed to be a powerful antioxidant, and conjugated linoleic acid may improve muscle mass.

Be that as it may, aside from giving you an energy boost, it is not likely that you will lose weight from taking this product because none of the ingredients, including caffeine, have ever been proven effective for aiding in weight loss. It is important to remember that just because an ingredient was scientifically tested or studied, this does not mean that it was proven.

Thus, PhenBurn 750 cannot realistically or truthfully provide you with a weight loss guarantee.

It is very important that you first speak with your medical professional before taking this product. The primary reason is it contains a significant amount of stimulants, including caffeine and multiple ingredients that contain caffeine (e.g green coffee, green tea, guarana, kola nut) among others, which means that the risk of insomnia and other adverse side effects are high. As such, this weight loss supplement should be avoided by anyone who has sensitivities to stimulants.

Users are instructed to take 2 capsules in total, per day: 1 capsule 15-30 minutes before breakfast with water and 1 capsule in the afternoon. Until caffeine tolerance is established, the recommended dose is 1 capsule per day.

When this review was written, 60 capsules (a one month supply) of PhenBurn 750 cost £34.95 ($54.00).

Update – August 2020

PhenBurn 750 is currently unavailable and has likely been discontinued. Although the eBody website still exists, the page for PhenBurn 750 does not. In fact, there is no mention of this product or any other product with the word “Phen” in its title.

Beware of Overdoing it with Stimulants

Although this diet pill is no longer available, there are other weight management aids on the market that contain just as much (and sometimes more) stimulant content. This is a common practice among manufacturers of products that have been developed to be marketed as nonprescription Phentermine alternatives.

While stimulants like caffeine can certainly help to provide a boost in mental alertness and give metabolism a boost, which can support weight management efforts, particularly those related to exercise, too much isn’t a good thing. In fact, the side effects associated with overdosing on stimulants including caffeine (e.g. jitters, restless, insomnia, rapid heartbeat, heart palpitations, headache, mood changes, digestive upset, anxiety, increased blood pressure, etc.), can outweigh any potential benefit they may provide.

Additionally, while several studies have found that caffeine can increase mental alertness and accelerate metabolism, there is no quality research to support claims that it can help with appetite suppression. In fact, according to a more recent research conducted in 2018, results of the study suggested that caffeine does not have an effect on appetite suppression.

Understand, this doesn’t mean that you should avoid all diet pills that contain caffeine. When taken in the right amounts and in combination with an appropriate weight management strategy, caffeine may be beneficial to some people, particularly in terms of combating fatigue. However, it is very important to make sure you are taking a product that is safe and right for you and doesn’t contain multiple stimulant ingredients, like in the case of PhenBurn 750, because this is likely to cause more harm than good.

Remember, if you should ever have any doubts or concerns about the ingredients within a formula, consulting your doctor is always best.

Ph.375

There is no shortage of Phentermine alternative OTC (over-the-counter) diet pill products and Ph.375 is another one on the list. According to the official website for this product, Ph.375 contains a new inX-5 Formula that is clinically researched and fast absorbing.

Ph.375 is marketed as both an appetite suppressant and fat burner. Among the claims for this product is that it will help you “shed those extra pounds for good.” It’s 100% natural formula will help you achieve a “slimmer, sexier you.”

More specifically Ph.375 claims to:

• Reduce stored fat and improve energy levels
• Decrease hunger pangs and food cravings
• Boost the body’s metabolism to help you stay fit
• Increase the temperature of the body (thermogenesis) to burn more calories

Of course, just as you should before you buy real Adipex diet pills, it’s important to learn about dietary supplements for weight loss before taking them. The following review will provide you with the information you need to know about Ph.375.

Who makes Ph.375?

This non-prescription dietary supplement and weight management aid is supplied and manufactured by Wolfson Berg Limited. This is a company well known in the supplements industry. It is based in Cyprus, but Ph.375 is produced in both the US and the UK.

Wolfson Berg Limited guarantees the highest-quality supplements manufactured on FDA-approved facilities. Keep in mind that simply because a product is made in a facility that may use FDA-approved practices, this does not mean that the product is FDA approved, effective or safe to use.

When this review of Ph.375 was written, a single bottle sold for $65.95. You could also purchase 2 bottles and get 1 free for $131.95, or buy 4 bottles and get 2 free for $263.95. This dietary supplement could be purchased on the official product page and there was also a 60-day money back guarantee and free shipping.

Considering each bottle contains enough servings to last a user for only one month, this is a rather expensive OTC diet pill.

How has Ph.375 been formulated to work?

This product claims that it works in multiple “proven ways” to help you shed your excess pounds. It works to:

• Burn fat – the natural ingredients supposedly boost your metabolism, which results in more fat burning and boosted energy levels.
• Stop the production of fat – Ph.375 can help prevent fat production before this process even starts, which can assist in the prevention of weight gain.
• Suppress appetite – when feelings of hunger are reduced, this can make it easier to stick to a healthy, calorie-conscious diet and avoid overeating.
• Give an energy boost – maintaining high levels of energy throughout the day can keep you motivated, making it easier to remain active.
• Improve mood – ingredients that have a positive effect on mood can help you feel better and avoid feeling cranky or glum, which can happen while dieting and negatively impact your progress.

What are in the ingredients in Ph.375?

The ingredient in the Ph.375 formula, according to the official website when this review was written, included: Chromium Picolinate, Calcium Carbonate, Cayenne Pepper, Artichoke Leaf Extract, Coleus Forskohlii, Caffeine, Citrus Aurantium, L-Carnitine.

The suggested use is to take 1 tablet 20 minutes prior to breakfast and 1 tablet 20 minutes prior to lunch. No more than 2 tablets should be taken per day. For optimal results, users should take Ph.375 in conjunction with a calorie-restricted diet and regular exercise regimen.

Is the Ph.375 formula effective for weight loss?

It is highly unlikely that this product will function exactly as the manufacturer claims on the official Ph.375 website. Each of these ingredients have been clinically researched regarding their effects on weight loss. However, none of them have been scientifically proven safe or effective in aiding in or causing long-term measurable fat loss.

For instance:

Chromium Picolinate – some research has found that it may help keep blood sugar levels regulated by improving how the body uses insulin. However, according to WebMD, weight loss research regarding chromium is conflicting and taking it by mouth does not seem to improve weight loss.

Calcium Carbonate – in Ph.375 calcium supposedly helps to prevent the storing of excess body fat. Some research has shown that calcium may possibly help to increase weight loss, lean body mass and fat loss in people on a low-calorie diet and those on a regular un-restricted diet. Still, possibly effective isn’t the same as being proven effective.

Cayenne Pepper – it is commonly thought that the capsaicin in cayenne pepper can speed up your metabolism and reduce food cravings. However, most research has discovered that it is most effective at reducing pain when applied to the skin.

Artichoke leaf – some studies claim that in can increase fullness, helping with appetite control. That said, the majority of studies have found that this chemical may lower cholesterol and protect the liver.

Coleus Forskohlii – forskolin may help to lower blood pressure by widening the blood vessels. Some research suggests that it may increase cellular levels of cyclic adenosine monophosphate. High levels of this has been associated with accelerated fat loss, but forskolin has never been proven effective for weight loss.

L- Carnitine – works by helping the body to produce energy, potentially helping you to burn excess fat. That said, it does not appear to lower body weight in obese and overweight individuals.

Caffeine – this well-known stimulant in Ph.375 stimulates the central nervous system. It can raise blood pressure and may also function like a diuretic, increasing urination frequency. Research has found that caffeine can help with mental alertness. It may also help some people feel less hungry and may boost metabolism.

Citrus Aurantium – also commonly known as bitter orange, this herb contains the stimulant synephrine. Like caffeine, synephrine affects the central nervous system. It can constrict the blood vessels, increase blood pressure and heart rate. Some research believes that it can boost metabolism and fat mobilization, especially when combined with caffeine. Other research has found that even when combined with other ingredients, bitter orange does not reduce weight.

The bottom line is that each of these ingredients require further study to determine how safe they are as a treatment for weight loss, as well as their true effects (if any) on fat loss.

Are there any Ph.375 side effects?

Although some individuals might not experience any issues when taking this dietary supplement, there is the potential for side effects. The most common side effects include: sleeplessness, restlessness, anxiety, jitters, nervousness, increased heart rate, increased blood pressure, nausea and vomiting.

Furthermore, the FDA has cautioned that taking citrus aurantium in combination with caffeine can increase the risk of serious cardiovascular effects (even in healthy individuals). These effects include fainting, high blood pressure, stroke and heart attack.

It should also be noted that the ingredients in Ph.375 may worsen symptoms of bipolar disorders and anxiety.

What to think about before taking Ph.375

You should consult with your healthcare provider prior to taking Ph.375. This is important even if you are a healthy adult. The reason is due to it containing citrus aurantium, especially since it also contains caffeine.

That being said, it is particularly important to talk with your doctor if you have an existing medical condition or are currently taking any medications (prescription or non-prescription) or other supplements.

Finally, you should avoid taking this product if you are under the age of 18, have high blood pressure, heart problems, are pregnant, nursing or planning to become pregnant.

Phen24

Phen24 is a nonprescription diet pill designed to provide 24 hour weight loss support and is an OTC (over-the-counter) alternative to prescription diet drugs like Phentermine. There is both a daytime and a night time formula and each one has been specially crafted with specific ingredients to help dieters seeking additional help with their conventional weight loss plan (healthy diet and regular exercise) in reaching their weight loss goals with greater effectiveness and speed. The full Phen24 system has been created to assist in the burning of fat, boosting energy, enhancing metabolism, lowering food cravings and helping you to sleep better at night.

More specifically, the daytime formula has been designed to increase metabolism to boost calorie burn and weight loss, give you more energy to help you power through your exercise and further boosting your metabolic rate, and burn more calories to help make weight loss a smooth and continual process. At the time that this review was written, the ingredients in Phen24 Day included: Caffeine, Cayenne Powder, Iodine, Zinc Citrate, Guarana Extract, Phenylalanine, Manganese, Copper Sulphate.

As for the night time formula, it lowers evening cravings to help you stay on track with your diet, it boosts night time metabolism to break down fats, carbohydrates and proteins even as you sleep, and since it doesn’t contain any stimulants, it promotes better sleep. When this review was created, the ingredients in Phen24 Night included: Glucomanan, Biotin, Molybdenum, Thiamine, Green Tea Extract, Griffonia Extract, Chromium Picolinate, Choline Bitartrate, Pantothenic Acid, Pyridoxine HCl, Ascorbic Acid, Hops Extract.

Users are instructed to take 1 Phen24 Day capsule in the morning with breakfast and to take 2 Phen24 Night capsules 15 minutes prior to their evening meal with 1 to 2 glasses of water. Furthermore, it is recommended that users eat early dinners due to the fact that late dinners can contribute to more belly fat. This product is meant to be used in conjunction with a healthy calorie-reduced diet and regular exercise.

When this review was written, a one month supply of Phen24 cost $84.99 and included two bottles: one Phen24 Day bottle containing 30 pills and one Phen24 Night bottle containing 60 pills. It could also be purchased from the official Phen24 product site.

Although many of the ingredients within Phen24 are commonly used in the OTC weight loss industry and many have been clinically studied, be advised that there is no guarantee that taking these products will contribute to measurable weight loss. Also, be advised that while the night time formula does not contain stimulants the daytime one does. Therefore this dietary supplement may not be the best choice for anyone who has sensitivity to stimulants like caffeine.

Prior to taking Phen24 it is advised that you first speak with your healthcare provider, especially if you are pregnant, planning to become pregnant, are nursing, or have a current medical condition or are taking any medications.