This “pharmacy grade” weight loss product has been designed to help make the weight loss process faster and easier.

The official website for Phen375 says that this diet pill has every property that makes the prescription diet drug Phentermine effective in promoting weight loss.

The Benefits of Phen375

This “advanced” formula supposedly offers three primary benefits:

  • Metabolism boosting – Increasing the body’s ability to burn fat.
  • Appetite suppression – Reducing appetite to avoid a buildup of fats in the body.
  • Energy enhancement – Containing strong stimulants, this supposedly helps to give an energy boost to encourage working out.

Moreover, the manufacturer claims that while users can enjoy similar benefits to Phentermine, Phen375 doesn’t have all of the adverse side effects that are associated with the popular diet drug: “Phen375 gives the benefits of Phentermine without the risk.”

What Are the Ingredients in This Diet Pill?

When this review was created, the Phen375 ingredients included:

  • L-Carnitine Tartrate,
  • Caffeine,
  • Calcium Carbonate,
  • Cayenne Capsicum,
  • Chromium Picolinate,
  • Dendrobium Nobile Extract,
  • Citrus Aurantium Extract,
  • Coleus Forskohlii Roots
  • Potassium Stearate

The claim is that each of these ingredients helps to benefit weight loss in some way.

For instance, Caffeine is believed to help suppress the appetite, boost energy and promote thermogenesis, which helps to increase metabolic rate.

Cayenne (or capsicum) is also believed to encourage thermogenesis, which raises body temperature and burns calories, quickly. L-Carnitine helps to burn fat and Citrus Aurantium acts as a natural stimulant that is said to boost metabolism.

Nonetheless despite these claims, there is no clinical evidence that these ingredients or the others in the formula are effective at helping a person lose weight. Therefore, regardless of what the manufacturer might claim regarding Phen375’s efficacy, there is no proof that it can improve weight loss efforts or cause measurable fat loss.

Potential Side Effects

It is important to point out that while Phen375 may not produce negative side effects like Phentermine, this does not mean that it is without adverse effects. This diet pill contains more than one stimulant in its formula which increases a user’s risk of experiencing unpleasant effects.

Among these include:

  • Jitters
  • Insomnia
  • Increased heart rate
  • Mood changes
  • Increased blood pressure
  • Anxiety
  • Rapid heartbeat

Since this is the case, those who take this product should watch their consumption of other stimulants, like caffeine (e.g. cola, tea, coffee), guarana (e.g. energy drinks) and should also make sure they are not allergic to any of the pill’s ingredients.

A single bottle (30 tablets) cost $69.95 at the writing of this Phen375 review. Compared to other similar weight loss products, this is quite expensive.

Prior to taking this OTC diet pill, it is strongly recommended that you consult with your medical practitioner to make sure that it is the right choice for you. This is particularly important if you have a known medical condition or are currently taking any medications (prescription or non-prescription) or herbal supplements to treat a health condition. Your doctor should also be consulted if you are pregnant, nursing or are planning on becoming pregnant.

Overall, the manufacturer makes many unsubstantiated claims about Phen375. Moreover, there is no clinical evidence that it is safe or effective for weight loss. The bottom line: it may be in your best interest to avoid this product and find a better-quality diet pill from a more reputable manufacturer.


There is no shortage of Phentermine alternative OTC (over-the-counter) diet pill products and Ph.375 is another one on the list. According to the official website for this product, Ph.375 contains a new inX-5 Formula that is clinically researched and fast absorbing.

Ph.375 is marketed as both an appetite suppressant and fat burner. Among the claims for this product is that it will help you “shed those extra pounds for good.” It’s 100% natural formula will help you achieve a “slimmer, sexier you.”

More specifically Ph.375 claims to:

• Reduce stored fat and improve energy levels
• Decrease hunger pangs and food cravings
• Boost the body’s metabolism to help you stay fit
• Increase the temperature of the body (thermogenesis) to burn more calories

Of course, just as you should before you buy real Adipex diet pills, it’s important to learn about dietary supplements for weight loss before taking them. The following review will provide you with the information you need to know about Ph.375.

Who makes Ph.375?

This non-prescription dietary supplement and weight management aid is supplied and manufactured by Wolfson Berg Limited. This is a company well known in the supplements industry. It is based in Cyprus, but Ph.375 is produced in both the US and the UK.

Wolfson Berg Limited guarantees the highest-quality supplements manufactured on FDA-approved facilities. Keep in mind that simply because a product is made in a facility that may use FDA-approved practices, this does not mean that the product is FDA approved, effective or safe to use.

When this review of Ph.375 was written, a single bottle sold for $65.95. You could also purchase 2 bottles and get 1 free for $131.95, or buy 4 bottles and get 2 free for $263.95. This dietary supplement could be purchased on the official product page and there was also a 60-day money back guarantee and free shipping.

Considering each bottle contains enough servings to last a user for only one month, this is a rather expensive OTC diet pill.

How has Ph.375 been formulated to work?

This product claims that it works in multiple “proven ways” to help you shed your excess pounds. It works to:

• Burn fat – the natural ingredients supposedly boost your metabolism, which results in more fat burning and boosted energy levels.
• Stop the production of fat – Ph.375 can help prevent fat production before this process even starts, which can assist in the prevention of weight gain.
• Suppress appetite – when feelings of hunger are reduced, this can make it easier to stick to a healthy, calorie-conscious diet and avoid overeating.
• Give an energy boost – maintaining high levels of energy throughout the day can keep you motivated, making it easier to remain active.
• Improve mood – ingredients that have a positive effect on mood can help you feel better and avoid feeling cranky or glum, which can happen while dieting and negatively impact your progress.

What are in the ingredients in Ph.375?

The ingredient in the Ph.375 formula, according to the official website when this review was written, included: Chromium Picolinate, Calcium Carbonate, Cayenne Pepper, Artichoke Leaf Extract, Coleus Forskohlii, Caffeine, Citrus Aurantium, L-Carnitine.

The suggested use is to take 1 tablet 20 minutes prior to breakfast and 1 tablet 20 minutes prior to lunch. No more than 2 tablets should be taken per day. For optimal results, users should take Ph.375 in conjunction with a calorie-restricted diet and regular exercise regimen.

Is the Ph.375 formula effective for weight loss?

It is highly unlikely that this product will function exactly as the manufacturer claims on the official Ph.375 website. Each of these ingredients have been clinically researched regarding their effects on weight loss. However, none of them have been scientifically proven safe or effective in aiding in or causing long-term measurable fat loss.

For instance:

Chromium Picolinate – some research has found that it may help keep blood sugar levels regulated by improving how the body uses insulin. However, according to WebMD, weight loss research regarding chromium is conflicting and taking it by mouth does not seem to improve weight loss.

Calcium Carbonate – in Ph.375 calcium supposedly helps to prevent the storing of excess body fat. Some research has shown that calcium may possibly help to increase weight loss, lean body mass and fat loss in people on a low-calorie diet and those on a regular un-restricted diet. Still, possibly effective isn’t the same as being proven effective.

Cayenne Pepper – it is commonly thought that the capsaicin in cayenne pepper can speed up your metabolism and reduce food cravings. However, most research has discovered that it is most effective at reducing pain when applied to the skin.

Artichoke leaf – some studies claim that in can increase fullness, helping with appetite control. That said, the majority of studies have found that this chemical may lower cholesterol and protect the liver.

Coleus Forskohlii – forskolin may help to lower blood pressure by widening the blood vessels. Some research suggests that it may increase cellular levels of cyclic adenosine monophosphate. High levels of this has been associated with accelerated fat loss, but forskolin has never been proven effective for weight loss.

L- Carnitine – works by helping the body to produce energy, potentially helping you to burn excess fat. That said, it does not appear to lower body weight in obese and overweight individuals.

Caffeine – this well-known stimulant in Ph.375 stimulates the central nervous system. It can raise blood pressure and may also function like a diuretic, increasing urination frequency. Research has found that caffeine can help with mental alertness. It may also help some people feel less hungry and may boost metabolism.

Citrus Aurantium – also commonly known as bitter orange, this herb contains the stimulant synephrine. Like caffeine, synephrine affects the central nervous system. It can constrict the blood vessels, increase blood pressure and heart rate. Some research believes that it can boost metabolism and fat mobilization, especially when combined with caffeine. Other research has found that even when combined with other ingredients, bitter orange does not reduce weight.

The bottom line is that each of these ingredients require further study to determine how safe they are as a treatment for weight loss, as well as their true effects (if any) on fat loss.

Are there any Ph.375 side effects?

Although some individuals might not experience any issues when taking this dietary supplement, there is the potential for side effects. The most common side effects include: sleeplessness, restlessness, anxiety, jitters, nervousness, increased heart rate, increased blood pressure, nausea and vomiting.

Furthermore, the FDA has cautioned that taking citrus aurantium in combination with caffeine can increase the risk of serious cardiovascular effects (even in healthy individuals). These effects include fainting, high blood pressure, stroke and heart attack.

It should also be noted that the ingredients in Ph.375 may worsen symptoms of bipolar disorders and anxiety.

What to think about before taking Ph.375

You should consult with your healthcare provider prior to taking Ph.375. This is important even if you are a healthy adult. The reason is due to it containing citrus aurantium, especially since it also contains caffeine.

That being said, it is particularly important to talk with your doctor if you have an existing medical condition or are currently taking any medications (prescription or non-prescription) or other supplements.

Finally, you should avoid taking this product if you are under the age of 18, have high blood pressure, heart problems, are pregnant, nursing or planning to become pregnant.

Fen HCL Capsules

Fen HCL capsules is a non-prescription weight loss product designed to provide effective appetite suppression and hunger control as well as helps to control blood sugar levels. This product comes from FenHCL and should not be confused with the company’s other product Fen HCL Tablets. Although also designed for weight loss, the time-released tablet product contains a different formula.

Each white and blue capsule is formulated from all natural ingredients, which include: 20:1 Hoodia Extract, Guarana Extract and a Proprietary Blend of Cha De Bugre, Ginseng, Citrus Aurantium, Magnolia Bark Extract and Black Pepper.

At the time that this review was written, a one month supply of Fen HCL capsules sold on Amazon for $29.99.

The recommended dosage is to take 1 or 2 capsules on an empty stomach about 30 minutes prior to breakfast and another 1 or 2 capsules prior to lunch. Users are cautioned not take the pills too late in the day because the ingredients within the formula may cause sleeplessness. Users are also advised to first speak with their healthcare professional prior to taking this product or any supplement when starting any exercise or diet program.

How effective is Fen HCL. For starters, this OTC diet pill is meant to be used in conjunction with diet and exercise for optimal results. Secondly, its claim that it can cause appetite suppression is unfounded. None of the supposed appetite suppression-causing ingredients (ex. hoodia, cha de bugre) have been clinically proven to curb appetite.

As for the other ingredients, ginseng is believed to possibly help enhance immune system, reduce blood sugar levels, boost endurance and improve mood. Gurana, which contains caffeine, can improve mental alertness and fat burning. Magnolia bark is thought to help lower anxiety, which could reduce stress-related eating. Black Pepper helps the body to absorb ingredients more effectively and citrus aurantium – more commonly known as bitter orange – naturally contains the stimulant synephrine, which is believed to help breakdown fat and can boost the effectiveness of caffeine.

Unfortunately, while it is true that synephrine can boost the effectiveness of caffeine, it can also increase the risk of its negative side effects including insomnia, jitters, anxiety, rapid heartbeat, etc. Even worse, the FDA warns that combining caffeine with synephrine can also increase the risk of high blood pressure, stroke and heart attack, even in healthy individuals.

In addition to combining ingredients that together have the potential to produce dangerous side effects, there is not scientific proof that taking any of the ingredients as part of the Fen HCL capsule formula or individually, will lead to weight loss or help you shed measureable fat.

Phenadrine Xtreme

Another Phentermine alternative diet pill from Biogen, Phenadrine Xtreme is a non-prescription diet pill that supposedly helps weight loss seekers to control their appetite, obtain long-lasting energy and thermogenesis. According to the information on the official product page, Phenadrine Xtreme’s formulation was created based on the “latest scientific research”.

The ingredients that make up the Phenadrine Xtreme formula include Green Coffee Bean extract (200mg), Natural Caffeine (200mg), Capsaicin (15mg), Chromium Polynicotinate (200µg), Hoodia Gordonii (400mg) and the Hardcore-Xtreme TM Blend [Yerba Mate, Octopamine HCl, Citrus Aurantium, N-acetyl-L-carnitine (680mg)]. One serving size is equal to 3 capsules.

The above list reveals that this product contains several ingredients and it is nice to see that the manufacturer has provided how much of each ingredient is in one serving (with the exception of the Hardcore-Xtreme TM Blend), which gives users an idea of just how much of each substance they are ingesting.

It also reveals that the formula contains many ingredients that are well known in the weight loss industry, such as green coffee bean, caffeine, chromium, hoodia, yerba mate, and citrus aurantium (bitter orange). Unfortunately, what is true about many of these well known ingredients is that they are not clinically proven to be safe or effective for weight loss.

Take Hoodia, for example, this herb, which has been touted for centuries as an appetite suppressant, has never been clinically proven to successfully have this effect on those who take it.

Furthermore, while it does contain stimulant ingredients that act as thermogenics and have been proven to boost mental focus, energy, and even improve fat burning when combined with exercise (ex. caffeine), Phenadrine Xtreme contains many stimulants. This may be more of a hindrance than a help. The reason is that stimulants like caffeine – which is also in the ingredients yerba mate and green coffee bean – can cause unwanted side effects like insomnia, fast heart rate, rapid heartbeat, dizziness, headache, jitters, etc. The more stimulants there are, the higher the risk of side effects occurring.

It should also be pointed out that citrus aurantium contains the stimulant synephrine, which enhances the effects of caffeine. This includes both its good effects and the bad ones. The FDA has cautioned that combining these two ingredients can be a dangerous combination, even for healthy individuals, with the potential to cause side effects like increased blood pressure, stroke and heart attack.

Overall, Phenadrine Xtreme appears to be a fat burner that is likely to give you an energy boost. If you are interested in trying this product, remember that it is better to be safe than sorry. Consult with your healthcare provider.


Fedramine is a non-prescription weight loss pill that was created by Internet Marketing Solutions Group, LLC to suppress appetite, boost metabolism and increase energy levels. Based on its name it is clear that this over-the-counter diet pill was designed to be used as an OTC alternative to prescription diet drugs like phentermine and also as an alternative to banned OTC weight loss supplement Ephedra.

At the time that this review was written, while you could purchase a bottle of Fedramine on the internet for around $45, an official product page did not exist. This could imply that the product has been discontinued or soon will be.

Each red and purple capsule contains the following ingredients: Citrus Aurantium, Metabromine, Green Tea, Chromium, White Willow Bark, and Guarana.

Research has found that citrus aurantium, also known as bitter orange, is an energy enhancer that works on the central nervous system. It contains a natural stimulant called synephrine. The belief is that it can help aid weight loss by burning body fat, and curbing appetite.

Metabromine is believed to have a stimulant effect without over-stimulating the nervous system, so it provides a boost of energy but is not as potent as caffeine.

Containing a group of antioxidants known as catechins as well as caffeine, green tea is believed to boost thermogenesis (burning fat as energy to produce heat) in the body and can help to boost metabolism.

Studies have found that Chromium can lower blood lipid levels and may help to produce weight loss. It may also lower insulin levels in individuals with type 2 diabetes.

White Willow Bark may help to reduce pain and inflammation. For weight loss, some believe that this herb can be beneficial because it helps to improve general feelings of wellbeing which may make it easier for people to stick with their goals and maintain motivation.

Guarana is naturally high in caffeine and can help a person feel more mentally alert and may also help to boost metabolism and lead to more fat burning when combined with physical activity. It may even suppress appetite in some people.

Unfortunately, in spite of some interesting findings, none of these ingredients have ever been sufficiently studied to solidly prove that they are effective for aiding in or causing weight loss. Even caffeine, which is a known energy booster and fat burner, won’t necessarily cause weight loss.

Furthermore, anyone who is interested in taking Fedramine should be aware that this product contains many stimulants, including 2 ingredients containing caffeine. Furthermore, it contains synephrine, which enhances the effects of caffeine (both good and bad). Therefore, while you will receive a greater energy boost, you will also be at a great risk of unpleasant side effects including insomnia, jitters, rapid heartbeat, anxiety and upset stomach. The combination of synephrine and caffeine may also lead to more serious risks including high blood pressure, heart attack and stroke. You should avoid taking this supplement too close to your bedtime.

If you are interested in taking Fedramine, you should first consult with your healthcare provider to make sure it is safe for you. Individuals under the age of 18, pregnant or nursing women and individuals with diabetes should avoid taking this product.

Phentagen Phenermine

Phentagen, also referred to as Phentagen Phenermine, is an over-the-counter (OTC) diet pill manufactured by Clementine Health. The claim is that it is a potent dietary supplement that contains “3 designer extracts” and other nutrients. It supposedly works by suppressing the appetite, increasing the conversion of food to energy rather than fat, and enhancinng mood as well as feelings of wellbeing.

Another claim is that Phentagen directly affects hormones by boosting the activity of the C-A-R-T hormone, which supposedly boosts metabolism and regulates hunger. It is also said to decrease the activity of the stress hormone NP-Y, which has been linked to obesity.

Although the product has been created as an OTC alternative to prescription diet drugs like Phentermine, it is unlikely to provide users with the same appetite suppressant results as the prescription medication it is attempting to emulate.

That being said, its formula contains Infinity DiCaffeine Malate, Chocamine, Green Tea Extract, Citrus Aurantium, Bioperine. Here’s how some research suggests that these ingredients may be beneficial to those seeking to lose weight:

Infinity DiCaffeine Malate is a proprietary blend containing caffeine and malic acid and is said to promote mental focus and stimulate thermogenesis. Green Tea is thought to enhance metabolism. Citrus aurantium (bitter orange) contains synephrine, a stimulant that is believed to be a thermogenic and improves the effects of caffeine. Bioperine can boost the body’s ability to absorb nutrients. Chocamine is also a proprietary blend composed of theobromine and it is said to be less potent than caffeine but also increases energy.

Although there is sufficient evidence to prove that caffeine can boost alertness and improve exercise performance, increasing fat burning potential, there is not enough scientific fact to prove that caffeine or any of the other ingredients in the Phentagen formula will effectively lead to fat loss that results in weight reduction.

Users are instructed to take two tablets per day with a glass of water and not to exceed this dosage. However, they are not directed as to when it would be best to take these pills, how to take them, or if they should be taken together or separately. Since Phentagen does contain caffeine and other stimulants, it would be prudent to avoid taking these pills late in the afternoon to prevent sleep disturbances or insomnia.

In addition to the risk of caffeine-related side effects including sleeplessness, jitters, rapid heartbeat, headache, etc., this supplement also contains synephrine, a stimulant that boosts both the good and bad effects of caffeine. Combining these two ingredients could lead to serious cardiovascular side effects, even in healthy individuals, such as increased blood pressure, fainting, stroke and heart attack.

When this review was written, there was no official product page for Phentagen Phenermine. Though it could be found for sale online at eBay for £29.95 ($42.00), even Amazon no longer carried it. This is likely an indication that the product has been discontinued.

Due to the fact that Phentagen is not easy to obtain, the fact that there is a lack of evidence that this supplement effectively works as a weight loss aid, and due to the potential risks associated with it, you are likely to find better OTC weight loss phentermine alternatives on the market. Talk to your doctor about your weight loss goals and your options. It is unwise to take any diet pill without first consulting with your healthcare provider.